Scars dermatix silicone gel 15 ml.

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Each dosage form 100 g of gel contains: Dimethicone powder: Excipient qs 100 g. APPLICATIONS AND USES THERAPEUTIC INDICATIONS: It is indicated to improve the appearance and elasticity of hypertrophic and keloid scars resulting from burns, surgical procedures and traumatic wounds. Also promotes resolution of patients with hypertrophic scars and scars developed. It is reported that not only is effective in treatment but also as a prophylactic. Applying the silicone gel after surgery to prevent the development of hypertrophic scars and keloids at 75 to 85% of cases. Pharmacokinetics MECHANISM OF ACTION EFFECTS Pharmacokinetics: No evidence of inflammation or foreign body reaction in scars treated with silicone gel, suggesting that silicone does not penetrate the treated tissue and not found silica in the scar. However, the release of compounds related to the silicone gel and silicone distribution was shown in in vitro skin. Dermatix, to be formulated with dimethicone, acts on the scars by two mechanisms: initially causes an increase in hydration, due to an occlusive effect upon the skin, which has been inhibited the proliferation of fibroblasts and the production Collagen, which in turn contributes to decreasesymptoms of pain and itching. It is thought that the silicone gel acts as if it were part of the stratum corneum, reducing hyperemia and fibrosis, isolating the surface of the skin from the environment and thus helps decrease the appearance of itching and scratching in the scar, alter the function of the stratum corneum to benefit the scars. It also produces a change in blood perfusion which causes the scar to soften and reduce faster than acupressure because a temperature difference between the skin treated with dermatix and surrounding skin occurs, which is believed to have significant effect on the kinetics of the collagenase. It has also been observed that treated scars obtained dermatix greater elasticity. Overall Dermatix initially modifies the texture, color followed and finally the volume of scars. CONTRAINDICATIONS Do not apply to open or fresh wounds, mucous membranes or in combination with topical antibiotics or other topical treatments. PRECAUTIONS Do not apply near the eyes. It can be applied in children and the elderly, and reach stain clothing if dermatix covered before drying. RESTRICTIONS OF USE DURING PREGNANCY AND BREASTFEEDING have not been reported. ADVERSE REACTIONS 10 to 25% of cases occurred maceration, rash, pruritus and infection, however, these problems diminishgradually increases as the time of application, maintaining good hygiene, preventing hot and humid environments. DRUG INTERACTIONS OTHER GENDER not been reported. CHANGES IN RESULTS OF LABORATORY TESTS have not been reported to date. PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility No reported to date teratogenic, mutagenic or carcinogenic. DOSAGE AND ADMINISTRATION Dermatix gel is applied 2 times daily to the lesion prior toilet with soap and water and drying perfect. We recommend applying a thin layer of Dermatix gel and let dry for 10 to 12 minutes before covering with clothing or use makeup. If you do not dry in this period, probably because the amount applied was excessive, so you should remove the excess and wait for it to dry. In hot climates, it is recommended to save Dermatix in refrigerator for faster drying. It is recommended to use at least 2 consecutive months. In ancient or very pronounced scars suggests using for over two months. Do not stop until you get the desired benefit. PRESENTATIONS Box 15 g tube. RECOMMENDED STORAGE: Keep tube tightly closed container at room temperature to no more than 25 ° C.

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